Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Good
Based on 7 Reviews
8.6
Supplement Facts
Serving Size:  1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%

Top Medical Research Studies

7
Vitamin B6 may influence IBS symptoms
We explored the relationship between vitamin B6 intake and the severity of symptoms in individuals with irritable bowel syndrome (IBS). Through a study involving 17 participants diagnosed with IBS according to the Rome II criteria, we gathered daily symptom reports and food intake logs over a week.

Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.

This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
Read More
In our exploration of how vitamin B6 influences irritable bowel syndrome (IBS), we conducted a controlled, double-blind study involving 25 IBS patients who met the Rome IV criteria. These individuals were randomly assigned to receive either a novel formulation combining Bifidobacterium longum BB536, Lactobacillus rhamnosus HN001, and vitamin B6, or a placebo for one month before switching treatments.

We observed significant improvements in several IBS symptoms when patients were treated with the vitamin B6 probiotic combination compared to the placebo. Specifically, abdominal pain showed a notable decrease of nearly 49%, and bloating symptoms dropped by over 36%. Furthermore, the overall severity of the disease lessened substantially, suggesting that vitamin B6 in conjunction with these probiotics may play an essential role in managing IBS.

The trial also revealed improvements in intestinal permeability, which is a key factor in gut health. We noted an increase in beneficial gut bacteria, which indicates a revitalization of the intestinal microbiota during treatment. While the study's findings support the benefits of the B6 probiotic blend in alleviating IBS symptoms, it is important to recognize that these symptoms could be related to the probiotics themselves rather than the vitamin B6 alone.
Read More
8
Vitamin B6 in IBS-C treatment
We conducted a study to assess the effectiveness of a dry jelly concentrate containing vitamin B6, along with inulin and curcumin, on patients with irritable bowel syndrome (IBS) with constipation (IBS-C). Fifty patients who met the criteria for IBS-C were divided into two groups. One group received the jelly drinks alongside a standard diet for two weeks, while the control group followed the standard diet only.

Throughout the study, we carefully monitored changes in abdominal pain, bloating, stool frequency, and overall quality of life. The results showed that those who consumed the jelly concentrate experienced significant improvements in several gastrointestinal parameters. For instance, stool frequency increased, abdominal pain decreased, and there was a notable enhancement in quality of life ratings.

It's worth mentioning that while vitamin B6 was part of the jelly formulation, the specific benefits attributed solely to vitamin B6 are difficult to isolate. The improvements in the jelly group indicate that the combination of ingredients worked well together to alleviate symptoms of IBS-C. However, the control group did show some improvement in pain and bloating, which suggests that dietary factors alone can also play a role.

Overall, the inclusion of this jelly concentrate could be a beneficial addition for patients suffering from IBS-C, particularly due to its positive effects on stool parameters and quality of life. The study did not report any significant adverse effects, making this product a potentially safe option for those looking to manage their symptoms.
Read More

Most Useful Reviews

10
Less stress
Despite my initial dislike of Solgar, these vitamins are brilliant! They are 100% effective. I've become calmer, less irritable, and the stress has passed, allowing me to stop worrying about trivial matters.
Read More
9.5
Condition improved
I became less irritable, my sleep normalised, and my overall condition improved. Excellent brand; I chose it without hesitation. I would appreciate it if you find this review helpful!
Read More
8.8
Calm and less irritable
Good soothing. I advise. All irritability and anger have subsided. I began a 6-week course after my friend, a pharmacist, suggested it, stating that this preparation is more expensive in our chemists. The course was prompted by my irritability, anger, and psychosis. After two weeks, I began to notice a difference; I became calmer and less irritable. I took 25 mg as it was my first time using vitamin B6.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
  • All Researches
In our exploration of how vitamin B6 influences irritable bowel syndrome (IBS), we conducted a controlled, double-blind study involving 25 IBS patients who met the Rome IV criteria. These individuals were randomly assigned to receive either a novel formulation combining Bifidobacterium longum BB536, Lactobacillus rhamnosus HN001, and vitamin B6, or a placebo for one month before switching treatments.

We observed significant improvements in several IBS symptoms when patients were treated with the vitamin B6 probiotic combination compared to the placebo. Specifically, abdominal pain showed a notable decrease of nearly 49%, and bloating symptoms dropped by over 36%. Furthermore, the overall severity of the disease lessened substantially, suggesting that vitamin B6 in conjunction with these probiotics may play an essential role in managing IBS.

The trial also revealed improvements in intestinal permeability, which is a key factor in gut health. We noted an increase in beneficial gut bacteria, which indicates a revitalization of the intestinal microbiota during treatment. While the study's findings support the benefits of the B6 probiotic blend in alleviating IBS symptoms, it is important to recognize that these symptoms could be related to the probiotics themselves rather than the vitamin B6 alone.
Read More
8
Vitamin B6 in IBS-C treatment
We conducted a study to assess the effectiveness of a dry jelly concentrate containing vitamin B6, along with inulin and curcumin, on patients with irritable bowel syndrome (IBS) with constipation (IBS-C). Fifty patients who met the criteria for IBS-C were divided into two groups. One group received the jelly drinks alongside a standard diet for two weeks, while the control group followed the standard diet only.

Throughout the study, we carefully monitored changes in abdominal pain, bloating, stool frequency, and overall quality of life. The results showed that those who consumed the jelly concentrate experienced significant improvements in several gastrointestinal parameters. For instance, stool frequency increased, abdominal pain decreased, and there was a notable enhancement in quality of life ratings.

It's worth mentioning that while vitamin B6 was part of the jelly formulation, the specific benefits attributed solely to vitamin B6 are difficult to isolate. The improvements in the jelly group indicate that the combination of ingredients worked well together to alleviate symptoms of IBS-C. However, the control group did show some improvement in pain and bloating, which suggests that dietary factors alone can also play a role.

Overall, the inclusion of this jelly concentrate could be a beneficial addition for patients suffering from IBS-C, particularly due to its positive effects on stool parameters and quality of life. The study did not report any significant adverse effects, making this product a potentially safe option for those looking to manage their symptoms.
Read More
7
Vitamin B6 may influence IBS symptoms
We explored the relationship between vitamin B6 intake and the severity of symptoms in individuals with irritable bowel syndrome (IBS). Through a study involving 17 participants diagnosed with IBS according to the Rome II criteria, we gathered daily symptom reports and food intake logs over a week.

Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.

This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
Read More

User Reviews

USERS' SCORE
Good
Based on 7 Reviews
8.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
10
Less stress
Despite my initial dislike of Solgar, these vitamins are brilliant! They are 100% effective. I've become calmer, less irritable, and the stress has passed, allowing me to stop worrying about trivial matters.
Read More
9.5
Condition improved
I became less irritable, my sleep normalised, and my overall condition improved. Excellent brand; I chose it without hesitation. I would appreciate it if you find this review helpful!
Read More
8.8
Calm and less irritable
Good soothing. I advise. All irritability and anger have subsided. I began a 6-week course after my friend, a pharmacist, suggested it, stating that this preparation is more expensive in our chemists. The course was prompted by my irritability, anger, and psychosis. After two weeks, I began to notice a difference; I became calmer and less irritable. I took 25 mg as it was my first time using vitamin B6.
Read More
8.8
Reduced irritability
Soothes well; all irritability and anger have disappeared. My skin feels smooth and soft since starting vitamin B6. A friend advised me on the pharmacist, saying that this medicine is pricier in our pharmacies, while it is much cheaper here. I noticed a change after two weeks—I became calmer and less irritable.
Read More
8
Less irritable
I take these vitamins during the second phase of my menstrual cycle, halving the dosage as it was too high. They are effective, and I’ve noticed I become slightly less irritable during this time.
Read More

Frequently Asked Questions

Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by a range of symptoms including abdominal pain, bloating, gas, and altered bowel habits, which can manifest as diarrhea, constipation, or a combination of both. The exact cause of IBS isn't fully understood, but it's believed to stem from a complex interplay of factors including gut sensitivity, changes in gut motility, and psychosocial elements such as stress or anxiety. IBS is often classified into different types based on the predominant symptoms, such as IBS with diarrhea (IBS-D), IBS with constipation (IBS-C), and a mixed type (IBS-M).

Managing IBS can be multifaceted, often requiring a tailored approach based on individual symptoms and triggers. Dietary changes are frequently recommended, including low-FODMAP diets, which involve reducing fermentable carbohydrates that can exacerbate symptoms. In addition to dietary adjustments, stress management techniques and medications aimed at addressing specific symptoms, such as anti-diarrheal agents or laxatives, may also be beneficial. Since IBS can significantly impact quality of life, consulting with a healthcare provider or a registered dietitian is essential for developing an effective management plan.

B6, also known as pyridoxine, is a water-soluble vitamin that plays a vital role in numerous physiological functions within the body. It is essential for the metabolism of proteins, carbohydrates, and fats, and is involved in the synthesis of neurotransmitters, which are critical for proper brain function and mood regulation. B6 also contributes to the production of hemoglobin, which is necessary for transporting oxygen in the blood, and aids in the maintenance of healthy immune function.

Most people can obtain sufficient B6 through a balanced diet that includes foods like poultry, fish, potatoes, chickpeas, bananas, and fortified cereals. However, some individuals may benefit from supplementation, particularly those with specific health conditions, dietary restrictions, or higher nutritional needs. The recommended dietary allowance (RDA) varies by age and gender, so it’s important to pay attention to your individual needs. Although B6 is generally safe, high doses from supplements can lead to side effects, so it’s always best to consult with a healthcare provider if you’re considering adding pyridoxine to your regimen.

Pyridoxine, also known as vitamin B6, plays a crucial role in maintaining overall health, including the proper functioning of the nervous and immune systems. Some studies have suggested that vitamin B6 may have a positive impact on gut health and could aid individuals suffering from gastrointestinal disorders, such as irritable bowel syndrome (IBS). For those with IBS, which is characterized by symptoms like abdominal pain, bloating, and irregular bowel habits, managing stress and maintaining good nutritional health are key components of treatment, and B6 may assist in these areas.

Though there is limited direct evidence linking pyridoxine specifically to IBS symptom relief, ensuring adequate levels of vitamin B6 may support the body's ability to cope with stress and inflammation, factors often exacerbating IBS symptoms. If you’re considering adding vitamin B6 to your regimen as a potential way to manage IBS, it's best to consult a healthcare professional to tailor an approach that is safe and effective for your individual needs. Dietary sources of B6 include chicken, fish, potatoes, chickpeas, bananas, and fortified cereals, which can easily be included in a balanced diet.

Based on user reviews, many individuals taking this supplement for Irritable Bowel Syndrome have reported noticing results within a timeframe of about two weeks. For example, one reviewer shared that they began to notice improvements after just two weeks of starting the vitamin B6 regimen, noting that they felt calmer and less irritable during that period (Read Review). Similarly, others have echoed this experience, with reported benefits kicking in around the same two-week mark, leading to a decrease in irritability and an overall improvement in mood (Read Review).

While results may vary depending on individual circumstances, the general consensus is that many users started feeling the positive effects within the first two weeks of consistent use. A few reviewers noted that after a longer period, like six weeks, they experienced even further improvement in their condition, suggesting that ongoing use may enhance the benefits seen in the initial weeks (Read Review). Thus, if you're considering this supplement, be prepared for an initial wait of about two weeks to gauge its effectiveness in managing symptoms of Irritable Bowel Syndrome.

The research indicates that vitamin B6 may be beneficial for individuals with Irritable Bowel Syndrome (IBS), particularly when used in combination with probiotics or other supportive ingredients. A controlled study demonstrated that a novel formulation containing vitamin B6 and specific probiotics significantly improved symptoms such as abdominal pain and bloating in IBS patients, suggesting that this combination could play a vital role in managing the condition [1]. Additionally, another study focusing on a dry jelly containing vitamin B6 found notable enhancements in stool frequency and overall quality of life for those with IBS-C, though pinpointing the exact effect of vitamin B6 alone remains challenging [2].

Furthermore, research shows a concerning trend where individuals with IBS typically consume less than the recommended daily intake of vitamin B6, with lower intake correlated to more severe symptom reports [3]. While the evidence points towards the potential benefit of increasing vitamin B6 intake, particularly in conjunction with probiotics, the results highlight a need for further investigation to isolate the specific effects of vitamin B6. Consequently, those suffering from IBS might consider dietary adjustments or supplementation, but it's advisable to consult with a healthcare provider before making changes.

Based on user reviews, many individuals report significant improvements in their symptoms after taking vitamin B6. A consistent theme among users is the reduction in irritability and overall mood enhancement. One reviewer noted that after starting the regimen, their irritability and anger subsided, leading to a calmer demeanor just two weeks into their course (Read Review). Another user echoed similar sentiments, saying they experienced normalization of sleep and improvements in their overall condition after using the product (Read Review).

Other users have highlighted that the benefits continued to grow with ongoing use, where one noted that both irritability and fatigue decreased significantly after approximately two weeks (Read Review). While results can vary from person to person, the accumulated experiences suggest that many find vitamin B6 effective in promoting a sense of calmness and improved emotional wellbeing.

Users report that combining this supplement with other vitamins and minerals, such as magnesium, can enhance its effectiveness in managing symptoms related to Irritable Bowel Syndrome and irritability. One reviewer specifically mentioned that while they initially sought magnesium citrate, they incorporated vitamin B6 into their regimen and effectively noticed improvements in both mood and sleep quality within two weeks of consistent use (Read Review). Additionally, another user shared that taking vitamin B6 alongside magnesium contributed to reduced irritability and improved sleep, highlighting the complementary benefits of these supplements (Read Review).

Furthermore, some users have experimented with adjusting the dosage in conjunction with their menstrual cycle, noting that a lower dose still provided calming effects (Read Review). This suggests a level of flexibility in combining B6 with other supplements to tailor the approach according to individual needs. Overall, user feedback indicates that pairing vitamin B6 with magnesium and possibly other soothing agents can lead to significant benefits in managing both emotional and gastrointestinal symptoms associated with Irritable Bowel Syndrome.

Based on user reviews, individuals report varying experiences with the dosage of B6 Pyridoxine for addressing symptoms of Irritable Bowel Syndrome and related irritability. Several users noted significant improvements in their mood and irritability after commencing a regimen of B6. One user specifically mentioned taking 25 mg of B6, after recommendation from a pharmacist, which led to noticeable benefits within two weeks—including reduced anger and improved calmness (Read Review). Another user, who halved their dosage during the second phase of their menstrual cycle, still found the vitamins effective in reducing irritability (Read Review).

Additionally, a user suggested taking B6 in conjunction with magnesium, noting enhanced results like improved sleep and further reduction in irritability (Read Review). Overall, while effective dosages vary among individuals, a range of about 25 mg can be a useful starting point, with adjustments made based on personal response and any advice from healthcare professionals.

8.8
Calm and less irritable
Good soothing. I advise. All irritability and anger have subsided. I began a 6-week course after my friend, a pharmacist, suggested it, stating that this preparation is more expensive in our chemists. The course was prompted by my irritability, anger, and psychosis. After two weeks, I began to notice a difference; I became calmer and less irritable. I took 25 mg as it was my first time using vitamin B6.
8.8
Reduced irritability
Soothes well; all irritability and anger have disappeared. My skin feels smooth and soft since starting vitamin B6. A friend advised me on the pharmacist, saying that this medicine is pricier in our pharmacies, while it is much cheaper here. I noticed a change after two weeks—I became calmer and less irritable.
9.5
Condition improved
I became less irritable, my sleep normalised, and my overall condition improved. Excellent brand; I chose it without hesitation. I would appreciate it if you find this review helpful!
8.8
More cheerful
I bought this B6 for my husband, based on a cardiologist's recommendation, and began taking it too as I felt irritable and fatigued. I wanted a magnesium preparation that included B6, but I found that magnesium oxide is poorly absorbed. So, I purchased Magnesium Citrate from Solgar and B6 separately. After about two weeks, I noticed the benefits; I became calmer and more cheerful. For sleep issues, I suggest taking them in the evening. I recommend buying them.
8.5
Improved sleep
Good Vitamin! I took it with magnesium and became less irritable; my sleep also improved.
8
Less irritable
I take these vitamins during the second phase of my menstrual cycle, halving the dosage as it was too high. They are effective, and I’ve noticed I become slightly less irritable during this time.
In our exploration of how vitamin B6 influences irritable bowel syndrome (IBS), we conducted a controlled, double-blind study involving 25 IBS patients who met the Rome IV criteria. These individuals were randomly assigned to receive either a novel formulation combining Bifidobacterium longum BB536, Lactobacillus rhamnosus HN001, and vitamin B6, or a placebo for one month before switching treatments.

We observed significant improvements in several IBS symptoms when patients were treated with the vitamin B6 probiotic combination compared to the placebo. Specifically, abdominal pain showed a notable decrease of nearly 49%, and bloating symptoms dropped by over 36%. Furthermore, the overall severity of the disease lessened substantially, suggesting that vitamin B6 in conjunction with these probiotics may play an essential role in managing IBS.

The trial also revealed improvements in intestinal permeability, which is a key factor in gut health. We noted an increase in beneficial gut bacteria, which indicates a revitalization of the intestinal microbiota during treatment. While the study's findings support the benefits of the B6 probiotic blend in alleviating IBS symptoms, it is important to recognize that these symptoms could be related to the probiotics themselves rather than the vitamin B6 alone.
8
Vitamin B6 in IBS-C treatment
We conducted a study to assess the effectiveness of a dry jelly concentrate containing vitamin B6, along with inulin and curcumin, on patients with irritable bowel syndrome (IBS) with constipation (IBS-C). Fifty patients who met the criteria for IBS-C were divided into two groups. One group received the jelly drinks alongside a standard diet for two weeks, while the control group followed the standard diet only.

Throughout the study, we carefully monitored changes in abdominal pain, bloating, stool frequency, and overall quality of life. The results showed that those who consumed the jelly concentrate experienced significant improvements in several gastrointestinal parameters. For instance, stool frequency increased, abdominal pain decreased, and there was a notable enhancement in quality of life ratings.

It's worth mentioning that while vitamin B6 was part of the jelly formulation, the specific benefits attributed solely to vitamin B6 are difficult to isolate. The improvements in the jelly group indicate that the combination of ingredients worked well together to alleviate symptoms of IBS-C. However, the control group did show some improvement in pain and bloating, which suggests that dietary factors alone can also play a role.

Overall, the inclusion of this jelly concentrate could be a beneficial addition for patients suffering from IBS-C, particularly due to its positive effects on stool parameters and quality of life. The study did not report any significant adverse effects, making this product a potentially safe option for those looking to manage their symptoms.
7
Vitamin B6 may influence IBS symptoms
We explored the relationship between vitamin B6 intake and the severity of symptoms in individuals with irritable bowel syndrome (IBS). Through a study involving 17 participants diagnosed with IBS according to the Rome II criteria, we gathered daily symptom reports and food intake logs over a week.

Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.

This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.

References

  1. Bonfrate L, Di Palo DM, Celano G, Albert A, Vitellio P, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020;50:e13201. doi:10.1111/eci.13201
  2. Pilipenko VI, Teplyuk DA, Shakhovskaya AK, Isakov VA, Vorobyova VM, et al. [Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study]. Vopr Pitan. 2015;84:83.
  3. Ligaarden SC, Farup PG. Low intake of vitamin B6 is associated with irritable bowel syndrome symptoms. Nutr Res. 2011;31:356. doi:10.1016/j.nutres.2011.04.001
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